Studies show that almost a third of very premature babies develop sepsis late

Rannsókn sýnir að næstum þriðjungur afar fyrirbura þróa með sér blóðsýkingu seint

Credit: Pediatrics (2022). DOI: 10.1542/peds.2022-058813

Nearly one-third of very premature babies develop late-onset sepsis, a life-threatening infection that occurs more than three days after birth, according to a new study from the Children’s Hospital of Philadelphia (CHOP), in collaboration with the Vermont Oxford Network. The study, published today in Pediatricsalso found that 1 in 2 infants born at 23 weeks or earlier either died and/or contracted the infection.

“Late sepsis is associated with a higher risk of death or, for survivors, technology-dependent chronic illness,” said first author Dustin D. Flannery, DO, MSCE, a neonatologist at the Children’s Hospital of Philadelphia and an assistant professor. in Pediatrics at the University of Pennsylvania.

The researchers analyzed a large national sample of very preterm infants born at Vermont Oxford Network centers. Infants who died within the first 3 days after birth were excluded from the study. Of the 118,650 infants who participated in the study, 10,501 (8.9%) developed late-onset sepsis.

The researchers identified 34 pathogens that cause late-onset sepsis, the most common being coagulase-negative staphylococci (29%) and Staphylococcus aureus (23%). Infected infants were less likely to survive, and those who did had an increased risk of needing home oxygen, tracheostomy, and gastrectomy. One in 2 babies born at 23 weeks or earlier either died later and/or contracted the infection.

“These findings highlight a current challenge in our field: despite effective, coordinated national prevention efforts, infection rates have declined in recent years,” said Dr. Flannery said. “As life-saving resuscitation increases, we must find innovative ways to improve the prevention of late sepsis to improve outcomes for these patients.”

More information:
Dustin D. Flannery et al., Sepsis in very preterm infants, Pediatrics (2022). DOI: 10.1542/peds.2022-058813

Provided by Children’s Hospital of Philadelphia

Quotation: Study shows nearly one-third of extremely premature infants develop sepsis late (2022, November 11) retrieved November 13, 2022 from -late onset .html

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